Dosage protocol · Metabolic & Weight Loss
5-Amino-1MQ 50 mg
Typical daily range: 2.5–5 mg once or twice daily (subcutaneous).
- Reconstitute: Add 4.0 mL bacteriostatic water → 12.5 mg/mL concentration.
- Typical daily range: 2.5–5 mg once or twice daily (subcutaneous).
- Easy measuring: At 12.5 mg/mL, 1 unit = 0.01 mL = 0.125 mg (125 mcg) on a U-100 insulin syringe.
- Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within 2–4 weeks.
BAC water4.0mL
Concentration12.5mg/mL
Reconstitution
5-Amino-1MQ dosage chart
5-Amino-1MQ dosage chart
| Phase | Dose | Draw |
|---|---|---|
| Days 1–2 (Tolerance) | 2.5 mg once daily | 20 units0.20 mL |
| Days 3+ (Standard) | 5 mg once daily | 40 units0.40 mL |
| Alternative BID | 2.5 mg twice daily | 20 units × 20.20 mL |
How much to draw
The Draw column shows exactly where to stop on a U-100 insulin syringe. Different vial size or dose? The calculator below recomputes it live.
Supplies needed
Supplies needed
Peptide vial
The lyophilized compound
Bacteriostatic water
For reconstitution
U-100 insulin syringes
One per injection
Alcohol swabs
Stopper + site each time
How it works
5-Amino-1MQ is frequently marketed and searched for as a "peptide," but that label is chemically inaccurate. The compound, formally 5-amino-1-methylquinolinium, is a small synthetic molecule rather than a chain of amino acids, and it is listed as such in chemical databases like PubChem and the FDA's Global Substance Registration System.[1] It is studied as a selective, membrane-permeable inhibitor of an enzyme called nicotinamide N-methyltransferase, or NNMT.
Because online body-composition and longevity content often lumps metabolic research compounds together with true peptides, 5-Amino-1MQ shows up in peptide-therapy searches despite its distinct chemical class. Common naming variants include 5-Amino-1MQ, 5-amino-1-methylquinolinium, 5-AMQ, and 5A-1MQ, all referring to the same research molecule.
Benefits & side effects
The evidence for 5-Amino-1MQ is almost entirely preclinical. In diet-induced obese mice, the compound reduced body weight, white fat mass, adipocyte size, and cholesterol without changing how much the animals ate. A follow-up study combining the compound with a reduced-calorie diet reported improved body composition and liver fat compared to diet change alone. Separate work in aged mice examined effects on muscle stem cell activity and regeneration, and rat pharmacokinetic studies have characterized how the compound is absorbed and cleared.
No completed human efficacy trials for 5-Amino-1MQ were identified in the scientific and regulatory sources reviewed for this article. Claims about fat loss, longevity, mitochondrial health, or disease treatment in humans remain unproven extrapolations from animal and cell data, and should be read as research hypotheses rather than established outcomes.
Calculator
Plan your own dose
Reconstituting a different vial size or targeting a different dose? Run the numbers.
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