Dosage protocol · Experimental Research
Adipotide 10 mg
Starting dose: 250 mcg once daily; gradual escalation by 250 mcg every 2 weeks as tolerated.
- Reconstitute: Add 3.0 mL bacteriostatic water (max vial capacity) → ~3.33 mg/mL concentration.
- Starting dose: 250 mcg once daily; gradual escalation by 250 mcg every 2 weeks as tolerated.
- Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.33 mcg on a U‑100 insulin syringe.
- Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles[5].
BAC water3.0mL
Concentration3.33mg/mL
Reconstitution
Adipotide dosage chart
Adipotide dosage chart
| Week | Dose | Draw |
|---|---|---|
| Weeks 1–2 | 250 mcg | 7.5 units0.08 mL |
| Weeks 3–4 | 500 mcg | 15 units0.15 mL |
| Weeks 5–6 | 750 mcg | 22.5 units0.23 mL |
| Weeks 7–8 | 1000 mcg1.0 mg | 30 units0.30 mL |
How much to draw
The Draw column shows exactly where to stop on a U-100 insulin syringe. Different vial size or dose? The calculator below recomputes it live.
Supplies needed
Supplies needed
Peptide vial
The lyophilized compound
Bacteriostatic water
For reconstitution
U-100 insulin syringes
One per injection
Alcohol swabs
Stopper + site each time
How it works
Adipotide is an experimental research peptide also known as FTPP (fat-targeted proapoptotic peptide) or Prohibitin-TP01. It is described as a chimeric 25-amino-acid peptide combining a fat-targeting sequence, a cell-death-inducing motif, and a short linker.[1] Rather than acting through appetite hormones like most obesity drugs, it was engineered to home in on blood vessels supplying white adipose (fat) tissue.
Its scientific record rests almost entirely on animal research and one small early-phase human trial, not on approved medical use. Deliberately damaging tissue vasculature to shrink the fat it supports is a fundamentally different, more invasive strategy than appetite- or hormone-based weight-loss compounds.
Benefits & side effects
The strongest data come from a 2011 study in obese rhesus monkeys: daily subcutaneous Adipotide for 28 days reduced body weight, waist circumference, and imaged white fat, and improved insulin-resistance markers.[2] Earlier rodent work supported the same general concept and linked it to improved glucose tolerance.
Human evidence is limited to one registered Phase 1 trial (NCT01262664) in patients with advanced prostate cancer and obesity, designed to find a maximum tolerated dose rather than prove weight-loss benefit.[8] No published, controlled human efficacy trial exists. The gap between striking primate results and this narrow safety study is why Adipotide remains investigational rather than proven.
Calculator
Plan your own dose
Reconstituting a different vial size or targeting a different dose? Run the numbers.
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