Dosage protocol · Bioregulators
Cortagen 20 mg
Typical daily range: 1000–2000 mcg once daily (morning administration preferred).
- Reconstitute: Add 3.0 mL bacteriostatic water → 6.67 mg/mL (6670 mcg/mL) concentration.
- Typical daily range: 1000–2000 mcg once daily (morning administration preferred).
- Easy measuring: At 6.67 mg/mL, 1 unit = 0.01 mL ≈ 66.7 mcg on a U-100 insulin syringe.
- Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.
BAC water3.0mL
Concentration6.67mg/mL
Reconstitution
Cortagen dosage chart
Cortagen dosage chart
| Week | Dose | Draw |
|---|---|---|
| Weeks 1–2 | 1000 mcg | 15 units0.15 mL |
| Weeks 3–4 | 2000 mcg | 30 units0.30 mL |
How much to draw
The Draw column shows exactly where to stop on a U-100 insulin syringe. Different vial size or dose? The calculator below recomputes it live.
Supplies needed
Supplies needed
Peptide vial
The lyophilized compound
Bacteriostatic water
For reconstitution
U-100 insulin syringes
One per injection
Alcohol swabs
Stopper + site each time
How it works
Cortagen is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Pro, abbreviated AEDP, listed in PubChem as H-Ala-Glu-Asp-Pro-OH with molecular formula C17H26N4O9.[1] It belongs to a category of short peptides sometimes called bioregulators, a term used mainly in Russian and Eastern European literature for peptides studied for effects on gene expression and tissue-specific biology.
A 2004 paper describing its development states Cortagen was created through directed synthesis based on amino acid analysis of Cortexin, a natural, multi-component peptide preparation from brain cortex tissue.[2] As a single, defined sequence, Cortagen is chemically simpler than Cortexin, but that does not make its clinical effects better established.
Benefits & side effects
Cortagen's evidence base is overwhelmingly preclinical. In a rat sciatic-nerve-injury model, intramuscular Cortagen increased nerve-fiber growth rate and conduction velocity during regeneration.[4] Mouse studies of locomotor activity and anxiety-related behavior found effects that varied by dose and, at some regimens, appeared anxiogenic rather than calming.[7]
- Rat and mouse brain-ischemia studies examined related neurospecific peptide preparations for antioxidant and neuroprotective activity[5][6]
- An in vitro study found Cortagen induced interleukin-2 gene expression less strongly than two related bioregulator peptides[13]
- A 2015 study of lymphocytes from adults over 80 examined effects on age-related chromatin structure, offering early human-cell context, not a clinical trial[14]
No large, modern human trial of Cortagen was identified. Claims that it improves memory, treats dementia or brain injury, or reverses cognitive decline are unproven extrapolations from animal and cell-based findings.
Calculator
Plan your own dose
Reconstituting a different vial size or targeting a different dose? Run the numbers.
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