Dosage protocol · Growth Hormone & Performance
IGF-1 LR3 1 mg
Typical daily range: 20–50 mcg once daily subcutaneously (gradual titration recommended).
- Reconstitute: Add 3.0 mL bacteriostatic water → ~0.333 mg/mL concentration (333 mcg/mL).
- Typical daily range: 20–50 mcg once daily subcutaneously (gradual titration recommended).
- Easy measuring: At 0.333 mg/mL, 1 unit = 0.01 mL ≈ 3.33 mcg on a U-100 insulin syringe.
- Storage: Lyophilized: freeze at −20 °C (−4 °F) for up to 12 months; after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within 30 days; avoid repeated freeze–thaw cycles.
BAC water3.0mL
Concentration0.333mg/mL
Reconstitution
IGF-1 LR3 dosage chart
IGF-1 LR3 dosage chart
| Week | Dose | Draw |
|---|---|---|
| Weeks 1–2 | 20 mcg0.02 mg | 6 units0.06 mL |
| Weeks 3–4 | 40 mcg0.04 mg | 12 units0.12 mL |
| Weeks 5–8 | 50 mcg0.05 mg | 15 units0.15 mL |
How much to draw
The Draw column shows exactly where to stop on a U-100 insulin syringe. Different vial size or dose? The calculator below recomputes it live.
Supplies needed
Supplies needed
Peptide vial
The lyophilized compound
Bacteriostatic water
For reconstitution
U-100 insulin syringes
One per injection
Alcohol swabs
Stopper + site each time
How it works
IGF-1 LR3, also called Long R3 IGF-I, is a synthetic analog of human insulin-like growth factor 1 described in the literature as an 83-amino-acid molecule carrying an arginine-related substitution at position 3 and an extended structure compared with native IGF-1.[1] Native IGF-1 is an endogenous hormone involved in cell growth and metabolism; IGF-1 LR3 is a laboratory-engineered variant of it, not interchangeable with it.
IGF-1 LR3 is also frequently confused with mecasermin, the only FDA-approved recombinant human IGF-1 drug, and with IGF-1 DES, a different truncated IGF-1 analog. All three belong to the same growth-factor family but differ in structure, evidence base, and regulatory status.
Benefits & side effects
Direct human clinical research on IGF-1 LR3 as a therapeutic agent is limited, and no FDA-approved label defines an indication, dosing regimen, or safety profile for it. Most of what is published comes from cell-culture and animal studies of receptor binding, potency, and tissue growth — useful for understanding mechanism but not for establishing human efficacy or safety.[13][14]
Claims that IGF-1 LR3 builds muscle, accelerates tissue repair, or reduces body fat in humans rely on extrapolation from IGF-1 pathway biology in muscle hypertrophy research, not on controlled human trials of IGF-1 LR3 itself. The one human clinical-evidence base in this drug family belongs to mecasermin, which has demonstrated increased growth velocity in children with severe primary IGF-1 deficiency — a distinct molecule, population, and indication that does not transfer to IGF-1 LR3.
Calculator
Plan your own dose
Reconstituting a different vial size or targeting a different dose? Run the numbers.
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