Dosage protocol · Skin & Cosmetic
PT-141 + Melanotan II Stack 10 mg
PT-141 dose: 750–1750 mcg on-demand (≥45 min before activity); max 1 dose per 24 h.
- Reconstitute each: Add 3.0 mL bacteriostatic water → ~3.33 mg/mL concentration.
- PT-141 dose: 750–1750 mcg on-demand (≥45 min before activity); max 1 dose per 24 h.
- Melanotan II dose: 250–1000 mcg once daily with gradual titration.
- Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U-100 insulin syringe.
BAC water3.0mL
Concentration3.33mg/mL
Reconstitution
PT-141 + Melanotan II Stack dosage chart
PT-141 + Melanotan II Stack dosage chart · 1
| Phase | Dose | Draw |
|---|---|---|
| Initial / Titration | 500–750 mcg | 15–22 units0.22 mL |
| Standard | 1000–1500 mcg | 30–45 units0.45 mL |
| Full / FDA-Approved | 1750 mcg1.75 mg | 52 units0.52 mL |
PT-141 + Melanotan II Stack dosage chart · 2
| Week | Dose | Draw |
|---|---|---|
| Week 1 | 250 mcg | 7.5 units*0.075 mL |
| Week 2 | 500 mcg | 15 units0.15 mL |
| Weeks 3–4 | 750 mcg | 22 units0.22 mL |
| Weeks 5+ (Loading) | 1000 mcg | 30 units0.30 mL |
| Maintenance | 500–1000 mcg2–3×/week | 15–30 units0.30 mL |
How much to draw
The Draw column shows exactly where to stop on a U-100 insulin syringe. Different vial size or dose? The calculator below recomputes it live.
Supplies needed
Supplies needed
Peptide vial
The lyophilized compound
Bacteriostatic water
For reconstitution
U-100 insulin syringes
One per injection
Alcohol swabs
Stopper + site each time
How it works
Melanotan II is a synthetic peptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH), a hormone that acts on the melanocortin receptor family. It built an online reputation as a "tanning injection," but it was never itself developed into an approved medicine.
Two related melanocortin peptides did reach approval for narrow, specific indications: afamelanotide (Scenesse) for a rare light-sensitivity disorder, and bremelanotide (Vyleesi) for a specific sexual-desire disorder in premenopausal women.[10] That shows the receptor family has real drug potential — it does not mean melanotan II itself is approved or interchangeable with those products.
Benefits & side effects
Human evidence is limited to small, decades-old studies. A pilot Phase I study evaluated pigmentation changes and tolerability in a small group of participants.[2] A separate small double-blind, placebo-controlled crossover study tested melanotan II in men with psychogenic erectile dysfunction and reported increased erectile responses compared with placebo.[7]
Both studies were designed to test biological plausibility in small samples, not to establish a safe consumer product. No large modern trials and no FDA drug-development program exist for melanotan II itself.
Calculator
Plan your own dose
Reconstituting a different vial size or targeting a different dose? Run the numbers.
1
Reconstitution
mg
mL
Concentration—
Per unit (0.01 mL)—
Per 10 units (0.1 mL)—
2
Your dose
Doses per vial—
Vial lasts—
Draw to
— units
=
—
Other vial sizes
