Dosage protocol · Growth Hormone & Performance
Sermorelin 5 mg
Typical daily range: 200–500 µg once daily at bedtime (gradual titration).
- Reconstitute: Add 3.0 mL bacteriostatic water → ~1.67 mg/mL concentration.
- Typical daily range: 200–500 µg once daily at bedtime (gradual titration).
- Easy measuring: At 1.67 mg/mL, 1 unit = 0.01 mL ≈ 16.7 µg on a U‑100 insulin syringe.
- Storage: Lyophilized: refrigerate at 2–8 °C (36–46 °F); after reconstitution, refrigerate at 2–8 °C (36–46 °F) and use within 10–14 days[4].
BAC water3.0mL
Concentration1.67mg/mL
Reconstitution
Sermorelin dosage chart
Sermorelin dosage chart
| Week | Dose | Draw |
|---|---|---|
| Weeks 1–2 | 200 µg | 12 units0.12 mL |
| Weeks 3–4 | 300 µg | 18 units0.18 mL |
| Weeks 5–6 | 400 µg | 24 units0.24 mL |
| Weeks 7–8 | 500 µg | 30 units0.30 mL |
How much to draw
The Draw column shows exactly where to stop on a U-100 insulin syringe. Different vial size or dose? The calculator below recomputes it live.
Supplies needed
Supplies needed
Peptide vial
The lyophilized compound
Bacteriostatic water
For reconstitution
U-100 insulin syringes
One per injection
Alcohol swabs
Stopper + site each time
How it works
Sermorelin is a synthetic peptide analog of growth hormone-releasing hormone (GHRH), often described as GRF 1-29 because it reproduces the biologically active first 29 amino acids of the full-length hormone.[1] It belongs to a drug class called growth hormone secretagogues: compounds that prompt the body's own pituitary gland to release growth hormone, rather than supplying growth hormone directly the way recombinant somatropin (HGH) does.
Sermorelin has a notable regulatory history. It was previously marketed in the United States as an FDA-approved prescription drug (brand name Geref) for evaluating and treating pediatric growth hormone deficiency, but that approved product was later discontinued and is no longer commercially available. Today, sermorelin circulates mainly as a compounded or research-labeled peptide sold outside the FDA-approved drug pathway, which is a meaningfully different regulatory situation than an active, approved medication.
Benefits & side effects
The strongest evidence for sermorelin comes from its historical, labeled use in pediatric growth hormone deficiency, where it was studied for stimulating or diagnosing deficient growth hormone secretion in children under specialist endocrine care.[3] Guidelines from pediatric endocrine societies continue to frame growth hormone axis treatment as a diagnosis-driven, specialist-managed decision, not a general wellness intervention.
Evidence is much weaker for the anti-aging, sleep, and body-composition claims that dominate online marketing. A systematic review of growth hormone therapy in healthy older adults found only small body-composition changes alongside increased adverse events, and did not establish any anti-aging benefit.[4] Because sermorelin acts on the same growth hormone axis, that same caution applies: a plausible mechanism does not equal a proven benefit in otherwise healthy adults.
Calculator
Plan your own dose
Reconstituting a different vial size or targeting a different dose? Run the numbers.
1
Reconstitution
mg
mL
Concentration—
Per unit (0.01 mL)—
Per 10 units (0.1 mL)—
2
Your dose
Doses per vial—
Vial lasts—
Draw to
— units
=
—
Other vial sizes
