Dosage protocol · Growth Hormone & Performance
Ipamorelin 5 mg
Typical daily range: 100–250 mcg once daily (gradual titration recommended).
- Reconstitute: Add 3.0 mL bacteriostatic water → ~1.67 mg/mL concentration.
- Typical daily range: 100–250 mcg once daily (gradual titration recommended).
- Easy measuring: At 1.67 mg/mL, 1 unit = 0.01 mL ≈ 16.7 mcg on a U-100 insulin syringe.
- Storage: Lyophilized: 2–8 °C (35.6–46.4 °F) or freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within ~4 weeks.
BAC water3.0mL
Concentration1.67mg/mL
Reconstitution
Ipamorelin dosage chart
Ipamorelin dosage chart
| Week | Dose | Draw |
|---|---|---|
| Weeks 1–2 | 100 mcg | 6 units0.06 mL |
| Weeks 3–4 | 150 mcg | 9 units0.09 mL |
| Weeks 5–8 | 200 mcg | 12 units0.12 mL |
| Weeks 9–12 | 250 mcg | 15 units0.15 mL |
How much to draw
The Draw column shows exactly where to stop on a U-100 insulin syringe. Different vial size or dose? The calculator below recomputes it live.
Supplies needed
Supplies needed
Peptide vial
The lyophilized compound
Bacteriostatic water
For reconstitution
U-100 insulin syringes
One per injection
Alcohol swabs
Stopper + site each time
How it works
Ipamorelin is a synthetic pentapeptide (a chain of five amino acids) classified as a growth hormone secretagogue. The National Cancer Institute describes it as a ghrelin mimetic that binds the growth hormone secretagogue receptor (GHSR) and stimulates growth hormone release from the pituitary gland.[1] Unlike synthetic human growth hormone, which replaces GH directly, ipamorelin prompts the body's own pituitary cells to release more of it.
Early pharmacology research described ipamorelin as more "selective" than older growth hormone releasing peptides such as GHRP-6, because it stimulated GH release without the same rise in cortisol and ACTH seen with those compounds at tested doses.[2] That selectivity refers to hormone specificity in early studies, not an established safety advantage in humans.
Benefits & side effects
Human research on ipamorelin is narrower than online marketing suggests. Beyond the healthy-volunteer GH-response study, the most substantial clinical trial tested intravenous ipamorelin for postoperative ileus after bowel resection: a randomized, placebo-controlled proof-of-concept study of 117 patients found a median time to first tolerated meal of 25.3 hours with ipamorelin versus 32.6 hours with placebo — a difference that was not statistically significant.[4]
Commonly repeated claims about fat loss, lean muscle, better sleep, tissue repair, and anti-aging are largely extrapolated from broader growth hormone and IGF-1 biology, not demonstrated in ipamorelin-specific human trials. For comparison, a related but distinct peptide, tesamorelin, carries an FDA-approved indication for reducing excess abdominal fat in people with HIV-associated lipodystrophy — a narrow, approved use with no bearing on ipamorelin's unapproved status.[7]
Calculator
Plan your own dose
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